2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

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Chemical Name:2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one
CAS No.:1350444-65-3
Molecular Formula:C₂₄H₃₄N₂O₂
Molecular Weight:382.546
Hs Code.:

Synonyms:2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

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Chemical Property of 2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

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Technology Process of 2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

There total 9 articles about 2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1350445-35-0
C₂₅H₃₈N₂O₃

: 1350444-65-3
2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 192804-36-7
(4-(((benzyloxy)carbonyl)amino)phenyl)boronic acid

: 1350444-65-3
2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; acetylacetonatobis-(ethylene)rhodium(I) / 1,4-dioxane; water / 0.67 h / 20 - 105 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate / ethyl acetate

3: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

4: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

6: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

7: potassium tert-butylate / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; ethanol; potassium tert-butylate; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; acetylacetonatobis-(ethylene)rhodium(I); (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 1350444-65-3
2-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; acetylacetonatobis-(ethylene)rhodium(I) / 1,4-dioxane; water / 0.67 h / 20 - 105 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate / ethyl acetate

3: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

4: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

6: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

7: potassium tert-butylate / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; ethanol; potassium tert-butylate; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; palladium 10% on activated carbon; acetylacetonatobis-(ethylene)rhodium(I); (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;