(2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

Base Information

Chemical Name:(2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate
CAS No.:635727-04-7
Molecular Formula:C₁₇H₂₄O₆
Molecular Weight:324.374
Hs Code.:

Synonyms:(2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

Suppliers and Price of (2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

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Technology Process of (2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

There total 12 articles about (2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 635727-23-0
Benzoic acid (2R,4aR,5R,7R,8aS)-5-(2-hydroxy-ethyl)-4a-methyl-2-phenyl-tetrahydro-pyrano[4,3-d][1,3]dioxin-7-ylmethyl ester

: 635727-04-7
(2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; at 20 ℃; for 3h; atmospheric pressure;
DOI:10.1055/s-2004-822340

Reference yield:

: 635727-03-6
(2R,4aR,5R,7R)-5-allyl-7-iodomethyl-4a-methyl-2-phenyltetrahydropyrano[4,3-d][1,3]dioxane

: 635727-04-7
(2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / 1-methyl-pyrrolidin-2-one / 6 h / 100 °C

2.1: O₃; NaHCO₃ / methanol / -78 °C

2.2: Me₂S / methanol / 0.5 h / 0 °C

3.1: 313 mg / NaBH₄ / methanol / 0.5 h / 0 °C

4.1: 89 percent / H₂; AcOH / Pd/C / methanol / 3 h / 20 °C / atmospheric pressure

With sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; ozone; acetic acid; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1055/s-2004-822340

Reference yield:

: 635727-22-9
(2R,4aR,5R,7R)-5-allyl-4a-methyl-2-phenyltetrahydropyrano[4,3-d][1,3]dioxan-7-ylmethyl benzoate

: 635727-04-7
(2R,4S,5S,6R)-4-hydroxy-6-(2-hydroxyethyl)-5-hydroxymethyl-5-methyltetrahydropyran-2-ylmethyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃; NaHCO₃ / methanol / -78 °C

1.2: Me₂S / methanol / 0.5 h / 0 °C

2.1: 313 mg / NaBH₄ / methanol / 0.5 h / 0 °C

3.1: 89 percent / H₂; AcOH / Pd/C / methanol / 3 h / 20 °C / atmospheric pressure

With sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; ozone; acetic acid; palladium on activated charcoal; In methanol;
DOI:10.1055/s-2004-822340