2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

Base Information

Chemical Name:2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide
CAS No.:1429925-50-7
Molecular Formula:C₂₉H₃₄ClN₅O₂
Molecular Weight:520.074
Hs Code.:

Synonyms:2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

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Chemical Property of 2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

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Technology Process of 2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

There total 12 articles about 2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethanamine trihydrochloride

: 1429925-69-8
[7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid

: 1429925-50-7
2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

: 1429925-51-8
2-[(4S)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

Guidance literature:: [7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 0.25h;

(1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethanamine trihydrochloride; In 1,4-dioxane; at 80 ℃; for 4h;

Reference yield:

: 1429925-69-8
[7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid

: 1401425-98-6
(2S)-1-(4-methylpiperazin-1-yl)propan-2-amine trihydrochloride

: 1429925-50-7
2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

: 1429925-51-8
2-[(4S)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

Guidance literature:: [7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 0.25h;

(2S)-1-(4-methylpiperazin-1-yl)propan-2-amine trihydrochloride; In 1,4-dioxane; at 80 ℃; for 4h;

Reference yield:

: 1429500-48-0
ethyl [7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate

: 1429925-50-7
2-[(4R)-7-(3-chlorophenyl)-1-oxo-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / isopropyl alcohol / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1,4-dioxane / 0.25 h

2.2: 4 h / 80 °C

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; isopropyl alcohol;