N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

Base Information

Chemical Name:N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide
CAS No.:332015-46-0
Molecular Formula:C₂₄H₂₄BrN₃O
Molecular Weight:450.378
Hs Code.:

<i>N</i>-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1<i>H</i>-indol-3-yl)-<i>N</i>-pent-4-enyl-acetamide

Synonyms:N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

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Chemical Property of N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

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Technology Process of N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

There total 6 articles about N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 332015-45-9
(2-cyano-1-methyl-1H-indol-3-yl)-acetyl chloride

: 332015-44-8
(2-bromo-benzyl)-pent-4-enyl-amine

: 332015-46-0
N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 12h;
DOI:10.1039/b008465o

Reference yield:

: 5465-63-4
2-bromobenzylamine hydrochloride

: 332015-46-0
N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 0 °C

2.1: Cs₂CO₃ / dimethylformamide / 0.5 h / 80 °C

2.2: 93 percent / dimethylformamide / 3 h / 75 °C

3.1: 86 percent / K₂CO₃; PhSH / acetonitrile / 80 °C

4.1: 83 percent / diisopropylethylamine / CH₂Cl₂ / 12 h / 0 °C

With potassium carbonate; caesium carbonate; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b008465o

Reference yield:

: 1119-51-3
bromopentene

: 332015-46-0
N-(2-bromo-benzyl)-2-(2-cyano-1-methyl-1H-indol-3-yl)-N-pent-4-enyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cs₂CO₃ / dimethylformamide / 0.5 h / 80 °C

1.2: 93 percent / dimethylformamide / 3 h / 75 °C

2.1: 86 percent / K₂CO₃; PhSH / acetonitrile / 80 °C

3.1: 83 percent / diisopropylethylamine / CH₂Cl₂ / 12 h / 0 °C

With potassium carbonate; caesium carbonate; thiophenol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b008465o