(4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane

Base Information

• Chemical Name: (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane
• CAS No.: 224580-02-3
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 224580-02-3.mol

Synonyms:(4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane

Chemical Property of (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane

There total 2 articles about (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

p-Anisaldehyde dimethyl acetal (2186-92-7) + (2S,3R)-2,3,7-Trimethyl-oct-6-ene-1,3-diol (224579-91-3) → (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane (224580-02-3)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane;

DOI:10.1016/S0040-4039(99)00207-5

Reference yield:

(2R,3R)-3-methyl-3-(4-methyl-3-pentenyl)oxiranemethanol (50727-94-1,62777-72-4,62960-04-7,71030-55-2,76985-26-7,82188-73-6,112456-40-3,112456-65-2,62777-71-3) → (4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane (224580-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / diethyl ether

2: 93 percent / CSA / CH₂Cl₂

With camphor-10-sulfonic acid; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(99)00207-5

Reference yield: 86.0%

(4R,5S)-2-(4-Methoxy-phenyl)-4,5-dimethyl-4-(4-methyl-pent-3-enyl)-[1,3]dioxane (224580-02-3) → (2S,3R)-3-(4-Methoxy-benzyloxy)-2,3,7-trimethyl-oct-6-en-1-ol (224579-92-4)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane;

DOI:10.1016/S0040-4039(99)00207-5

upstream raw materials:

p-Anisaldehyde dimethyl acetal

(2S,3R)-2,3,7-Trimethyl-oct-6-ene-1,3-diol

(2R,3R)-3-methyl-3-(4-methyl-3-pentenyl)oxiranemethanol

Downstream raw materials:

(2S,3R)-3-(4-Methoxy-benzyloxy)-2,3,7-trimethyl-oct-6-en-1-ol

tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3-dimethyl-hex-5-enyloxy]-dimethyl-silane

tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3-dimethyl-4-(S)-oxiranyl-butoxy]-dimethyl-silane

tert-Butyl-[(2S,3R)-3-(4-methoxy-benzyloxy)-2,3,7-trimethyl-oct-6-enyloxy]-dimethyl-silane