2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

Base Information

Chemical Name:2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile
CAS No.:1097630-25-5
Molecular Formula:C₁₃H₁₄F₃NO₂S
Molecular Weight:305.321
Hs Code.:

Synonyms:2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

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Chemical Property of 2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

Chemical Property:

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Technology Process of 2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

There total 7 articles about 2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1097630-23-3
2-(4-ethynyl-4-hydroxycyclohexyl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

: 1097630-25-5
2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

: 1097630-24-4
2-(4-ethynyl-4-fluorocyclohexyl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1086602-99-4
2-(3,3,3-trifluoropropylthio)acetonitrile

: 1097630-25-5
2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

: 1097630-24-4
2-(4-ethynyl-4-fluorocyclohexyl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water / 1 h / 65 - 70 °C

2: rac-Pro-OH / toluene / 1 h / Reflux

3: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 °C

4: acetic acid / water / 10 h / 70 °C

5: tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

6: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; dihydrogen peroxide; acetic acid; rac-Pro-OH; sodium tungstate (VI) dihydrate; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 1097630-65-3
S-(3,3,3-trifluoropropyl)ethanethioate

: 1097630-25-5
2-(4-ethynyl-cyclohexen-3-yl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

: 1097630-24-4
2-(4-ethynyl-4-fluorocyclohexyl)-2-(3,3,3-trifluoropropylsulfonyl)acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / tetrahydrofuran; methanol / 1.25 h / 0 - 20 °C

1.2: 3 h / 0 - 20 °C

2.1: dihydrogen peroxide / sodium tungstate (VI) dihydrate / water / 1 h / 65 - 70 °C

3.1: rac-Pro-OH / toluene / 1 h / Reflux

4.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 °C

5.1: acetic acid / water / 10 h / 70 °C

6.1: tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

7.1: diethylamino-sulfur trifluoride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; dihydrogen peroxide; sodium methylate; acetic acid; rac-Pro-OH; sodium tungstate (VI) dihydrate; In tetrahydrofuran; methanol; dichloromethane; water; toluene;