<5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

Base Information

Chemical Name:<5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal
CAS No.:161488-95-5
Molecular Formula:C₂₂H₂₂FN₃O₅
Molecular Weight:427.432
Hs Code.:

Synonyms:<5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

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Chemical Property of <5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of <5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

There total 5 articles about <5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 161488-95-5
<5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 5 steps

1: 103.1 g / HCl / ethanol / 16 h / Ambient temperature

2: 53 percent / methanol / 72 h / 5 °C

3: 73 percent / methanol / 1.5 h / 100 °C

4: 89 percent / pyridine, lithium iodide / 2 h / Heating

5: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; triethylamine; lithium iodide; In methanol; ethanol;
DOI:10.1021/jm00001a015

Reference yield:

: 149742-96-1
N-(2,2-dimethoxyethyl)-4-(fluorophenyl)carboxamidine

: 161488-95-5
<5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / methanol / 1.5 h / 100 °C

2: 89 percent / pyridine, lithium iodide / 2 h / Heating

3: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

With pyridine; diphenyl phosphoryl azide; triethylamine; lithium iodide; In methanol;
DOI:10.1021/jm00001a015

Reference yield:

: 4-Fluoro-benzimidoyl chloride; hydrochloride

: 161488-95-5
<5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / methanol / 72 h / 5 °C

2: 73 percent / methanol / 1.5 h / 100 °C

3: 89 percent / pyridine, lithium iodide / 2 h / Heating

4: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

With pyridine; diphenyl phosphoryl azide; triethylamine; lithium iodide; In methanol;
DOI:10.1021/jm00001a015