Rocuronium bromide

Base Information

• Chemical Name: Rocuronium bromide
• CAS No.: 119302-91-9
• Molecular Formula: C32H53N2O4^.Br
• Molecular Weight: 609.69
• Hs Code.: 2934990002
• European Community (EC) Number: 601-597-6
• UNII: I65MW4OFHZ
• DSSTox Substance ID: DTXSID7023566
• Wikipedia: Rocuronium_bromide
• Wikidata: Q27108171
• NCI Thesaurus Code: C47709
• RXCUI: 32521
• Metabolomics Workbench ID: 53411
• ChEMBL ID: CHEMBL1200648
• Mol file: 119302-91-9.mol

Synonyms:1-(17-(acetoyl)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)pyrrolidinium;Androstane-3,17-diol, 2-(4-morpholinyl)-16-(1-(2-propen-1-yl)-1-pyrrolidiniumyl)-, 17-acetate, (2beta,3alpha,5alpha,16beta,17beta)-;Esmeron;Esmerone;ORG 9426;ORG-9426;ORG9426;pyrrolidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)-, bromide;rocuronium;rocuronium bromide;Zemuron

Chemical Property of Rocuronium bromide

Chemical Property:

• Appearance/Colour: white or off-white powder
• Melting Point: 162-164 ºC
• PSA: 59.00000
• Density: ==
• LogP: 1.30820
• Storage Temp.: Room temp
• Solubility.: H2O: soluble100mg/mL, clear, light yellow
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 608.31887
• Heavy Atom Count: 39
• Complexity: 898

Purity/Quality:

99%min ^*data from raw suppliers

Rocuronium bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]
• Isomeric SMILES: CC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]
• Recent ClinicalTrials: Effect of Magnesium Sulphate Pretreatment in Pediatric Laparoscopy
• Recent EU Clinical Trials: Recovery of carotid body function after full recovery neuromuscular block
• Recent NIPH Clinical Trials: Protective effect of rocuronium on ischemic myocyte injury induced by tourniquet.
• Uses: 1. It is a kind of muscle relaxants and a kind of non-depolarizing neuromuscular blocking agents. It is used as the adjuvant drugs for general anesthesia and conventional intubation of both inpatient and outpatient. It can keep the muscle relaxation during the process of mechanical ventilation and surgery. 2. It is used as a kind of skeletal muscle relaxants (non-depolarizing) A non-depolarizing neuromuscular blocker used in anesthesia to help insert breathing tubes. Aminosteroid, competitive neuromuscular blocker Aminosteroid, competitive neuromuscular blocker.
• Indications: Rocuronium bromide belongs to an adjuvant drug for general anesthesia used for tracheal intubation during routine induction of anesthesia for the maintenance of muscle relaxation of surgery.
• Description: Rocuronium bromide is a short-acting nondepolarizing steroidal neuromuscular blocker introduced in the U.S.A as Zemuron and in the United Kingdom as Esmeron. k is indicated for use as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Rocuroniurn bromide has a significantly more rapid onset than other intermediate acting neuromuscular blockers, comparable to succinylcholine but with a very stable cardiovascular profile and has an improved side effect profile. It has been reported that good to excellent intubation conditions were achieved only one minute after a bolus dose of 600μg/kg of rocuronium bromide. It has a short duration of action, therefore, is useful for rapid sequence intubation without unacceptable delays in the spontaneous recovery of neuromuscular function.
• Biological Functions: Rocuronium bromide (Zemuron) is a recently approved amino steroid neuromuscular blocking agent. It has a rapid onset of action (1 minute), but its duration of action is intermediate (55 minutes), about that of vecuronium. On rare occasions, it may release histamine and cause cardiac irregularities. Rapacuronium bromide (Raplon) is the most recent neuromuscular blocking agent approved by the United States Food and Drug Administration (FDA). It is an analogue of vecuronium and is thus categorized as an amino steroid. It has a rapid onset of action (1.5 minutes) and a short to intermediate duration of action (20 minutes).This makes it a suitable alternative to mivacurium or succinylcholine for short procedures. It is eliminated mainly by the liver.Adverse effects are dose dependent; they include tachycardia, hypotension, and bronchospasm. These effects may be related to the ability of the drug to release a small amount of histamine.
• Clinical Use: Muscle relaxant in general anaesthesia, medium duration