2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

Base Information

Chemical Name:2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester
CAS No.:1301608-68-3
Molecular Formula:C₅₂H₈₀N₆O₁₂
Molecular Weight:981.24
Hs Code.:

2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

Synonyms:2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

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Chemical Property of 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

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Technology Process of 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

There total 7 articles about 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1301608-54-7
malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

: 4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-oxyl radical

: 1301608-68-3
2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

Guidance literature:: malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester; With n-butyllithium; diisopropylamine; In 1,2-dimethoxyethane; hexane; at -60 ℃; for 0.5h;

4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-oxyl radical; With copper dichloride; In 1,2-dimethoxyethane; hexane; at -60 - 20 ℃; for 16h;
DOI:10.1002/chem.201003163

Reference yield:

: 1301608-53-6
Boc-phenylalanyl-alanyl-5-hydroxypentylamide

: 1301608-68-3
2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 4 h / 20 °C

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

3.1: triethylamine / dichloromethane / 16 h / 20 °C

4.1: n-butyllithium; diisopropylamine / 1,2-dimethoxyethane; hexane / 0.5 h / -60 °C

4.2: 16 h / -60 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; hexane; dichloromethane; water;
DOI:10.1002/chem.201003163

Reference yield:

: 1301608-52-5
Boc-alanyl-5-hydroxypentylamide

: 1301608-68-3
2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazine-1-yloxy)malonic acid [5-(N-Boc-O-Bn-seryl-phenylalanyl-alanylamido)pentyl] ester methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h

3.1: hydrogenchloride / 1,4-dioxane; water / 4 h / 20 °C

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

5.1: triethylamine / dichloromethane / 16 h / 20 °C

6.1: n-butyllithium; diisopropylamine / 1,2-dimethoxyethane; hexane / 0.5 h / -60 °C

6.2: 16 h / -60 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; hexane; dichloromethane; water;
DOI:10.1002/chem.201003163