N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

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Chemical Name:N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide
CAS No.:948893-97-8
Molecular Formula:C₃₂H₄₆N₄O₄Si
Molecular Weight:578.827
Hs Code.:

Synonyms:N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

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Chemical Property of N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

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Technology Process of N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

There total 11 articles about N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 948893-96-7
3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanoic acid

: 100-46-9
benzylamine

: 948893-97-8
N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

: 948893-97-8
N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine / N,N-dimethyl-formamide / 0 - 20 °C

2.1: sodium azide; sodium iodide / dimethyl sulfoxide / 3 h / 65 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3750.38 Torr

4.1: acetic acid / 1-methyl-pyrrolidin-2-one / 7 h / 20 °C

4.2: 18 h

5.1: trifluoroacetic acid / 2 h / 20 °C

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

With 2,6-dimethylpyridine; sodium azide; hydrogen; acetic acid; triethylamine; HATU; trifluoroacetic acid; sodium iodide; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 948893-97-8
N-benzyl-3-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; sodium iodide / dimethyl sulfoxide / 3 h / 65 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3750.38 Torr

3.1: acetic acid / 1-methyl-pyrrolidin-2-one / 7 h / 20 °C

3.2: 18 h

4.1: trifluoroacetic acid / 2 h / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

With sodium azide; hydrogen; acetic acid; triethylamine; HATU; trifluoroacetic acid; sodium iodide; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;