7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Base Information

Chemical Name:7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one
CAS No.:1221486-19-6
Molecular Formula:C₂₁H₁₇NO₂
Molecular Weight:315.371
Hs Code.:

Synonyms:7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

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Chemical Property of 7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

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Technology Process of 7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

There total 4 articles about 7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1221485-73-9
7-methoxy-2-(phenylamino)-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

: 1221486-19-6
7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Guidance literature:: With hydrogen bromide; acetic acid; In water; at 120 - 130 ℃; for 2h;
DOI:10.1021/jm300327h

Reference yield:

: 586-38-9
3-Methoxybenzoic acid

: 1221486-19-6
7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; acetic acid / water / 14 h / 90 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 85 - 112 °C

3.1: triphenylphosphine / methanol / 2 h / Reflux

3.2: 3.75 h / 0 °C

4.1: palladium on activated charcoal; hydrogen / ethyl acetate; acetonitrile / 5 h / 20 °C

5.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

5.2: 1.5 h / 20 °C

6.1: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

7.1: hydrogen bromide; acetic acid / water / 2 h / 120 - 130 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen bromide; hydrogen; palladium diacetate; acetic acid; triphenylphosphine; sodium t-butanolate; XPhos; In methanol; dichloromethane; water; ethyl acetate; chlorobenzene; toluene; acetonitrile; tert-butyl alcohol; 3.2: Wittig reaction / 5.2: Friedel Crafts reaction / 6.1: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h

Reference yield:

: 4741-63-3
6-methoxyphthalide

: 1221486-19-6
7-hydroxy-2-phenylamino-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 85 - 112 °C

2.1: triphenylphosphine / methanol / 2 h / Reflux

2.2: 3.75 h / 0 °C

3.1: palladium on activated charcoal; hydrogen / ethyl acetate; acetonitrile / 5 h / 20 °C

4.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

4.2: 1.5 h / 20 °C

5.1: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

6.1: hydrogen bromide; acetic acid / water / 2 h / 120 - 130 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen bromide; hydrogen; palladium diacetate; acetic acid; triphenylphosphine; sodium t-butanolate; XPhos; In methanol; dichloromethane; water; ethyl acetate; chlorobenzene; toluene; acetonitrile; tert-butyl alcohol; 2.2: Wittig reaction / 4.2: Friedel Crafts reaction / 5.1: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h