1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one

Base Information

• Chemical Name: 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one
• CAS No.: 1026493-15-1
• Molecular Formula: C₁₆H₁₆F₇NO
• Molecular Weight: 371.298

Synonyms:1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one

Chemical Property of 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one

There total 2 articles about 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentanoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (1027019-10-8) → 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one (1026493-15-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0200456

Reference yield:

tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate (115186-37-3) → 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one (1026493-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 - 20 °C

2: TFA / CH₂Cl₂ / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0200456

Reference yield:

monomethyl oxalyl chloride (5781-53-3) + 1-(S)-Pyrrolidin-2-yl-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentan-1-one (1026493-15-1) → Oxo-{(S)-2-[5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentanoyl]-pyrrolidin-1-yl}-acetic acid methyl ester (1026379-82-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1021/jm0200456

upstream raw materials:

2-[5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentanoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate

Downstream raw materials:

Oxo-{(S)-2-[5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pentanoyl]-pyrrolidin-1-yl}-acetic acid methyl ester

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