3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester

Base Information

• Chemical Name: 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester
• CAS No.: 864677-90-7
• Molecular Formula: C₂₁H₂₆O₄
• Molecular Weight: 342.435
• Mol file: 864677-90-7.mol

Synonyms:3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester

Chemical Property of 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester

There total 5 articles about 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C21H24O4 → 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester (864677-90-7)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.08.086

Reference yield: 76.0%

C16H17BrO2 (864677-86-1) + ethyl acrylate (140-88-5,9003-32-1) → 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester (864677-90-7)

Guidance literature:

With pyridine; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; ethylene dibromide; nickel dibromide; In N,N-dimethyl-formamide; at 100 ℃; Electrochemical reaction;

DOI:10.1055/s-2005-865364

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 3-{2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-propionic acid ethyl ester (864677-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

1.2: 95 percent / TBAI / tetrahydrofuran / 4 h / 50 °C

2.1: 76 percent / TBAB; TBAI; pyridine / 1,2-dbromoethane; NiBr₂*3H₂O / dimethylformamide / 100 °C / Electrochemical reaction

With pyridine; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; ethylene dibromide; nickel dibromide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1055/s-2005-865364

upstream raw materials:

C₁₆H₁₇BrO₂

ethyl acrylate

2-bromophenylethyl alcohol

p-methoxybenzyl chloride

Downstream raw materials:

3-[2-(2-hydroxy-ethyl)-phenyl]-propionic acid ethyl ester

3-[2-(2-hydroxy-ethyl)-phenyl]-propionic acid