3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

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Chemical Name:3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole
CAS No.:1088713-09-0
Molecular Formula:C₁₉H₂₁F₃N₂O₃S
Molecular Weight:414.449
Hs Code.:

Synonyms:3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

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Chemical Property of 3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

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Technology Process of 3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

There total 4 articles about 3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199125-21-8
3-(cyclopropyl)-1-methyl-1H-pyrazol-5-ol

: 3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoic acid chloride

: 1088713-09-0
3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

Guidance literature:: 3-cyclopropyl-1-methyl-1H-pyrazol-5-ol; 3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoic acid chloride; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

With potassium cyanide; triethylamine; 2-hydroxy-2-methylpropanenitrile; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 1070761-76-0
3-fluoro-2-methyl-4-trifluoromethylbenzoic acid

: 1088713-09-0
3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide

1.2: 15.17 h / 20 - 80 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.25 h / Heating / reflux

3.1: triethylamine / dichloromethane / 16 h / 20 °C

3.2: 16 h / 20 °C

With oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 115754-21-7
3-fluoro-4-(trifluoromethyl)benzoic acid

: 1088713-09-0
3-cyclopropyl-5-hydroxy-4-(3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoyl)-1-methylpyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -40 °C

1.2: 16 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 15.17 h / 20 - 80 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.25 h / Heating / reflux

4.1: triethylamine / dichloromethane / 16 h / 20 °C

4.2: 16 h / 20 °C

With n-butyllithium; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;