(2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

Base Information

Chemical Name:(2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide
CAS No.:113453-30-8
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:(2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

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Technology Process of (2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

There total 3 articles about (2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 3587-60-8
Benzyloxymethyl chloride

: 113453-29-5
(2S,3R,4E)-3-hydroxy-N-methoxy-N,2-dimethyl-5-phenyl-4-pentenamide

: 113453-30-8
(2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 38h; Ambient temperature;
DOI:10.1021/ja00216a026

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 113453-30-8
(2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

Guidance literature:: Multi-step reaction with 3 steps

2: 1) AlMe₃ / 1) CH₂Cl₂, 30 min, room temp., toluene; 2) CH₂Cl₂, 0-10 deg C

3: 94 percent / i-Pr₂EtN, Bu₄NI / tetrahydrofuran / 38 h / Ambient temperature

With trimethylaluminum; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ja00216a026

Reference yield:

: 113453-28-4
<3(2S,3R,4E),4S>-3-(-3-hydroxy-2-methyl-1-oxo-5-phenyl-4-penteyl)-4-(phenylmethyl)-2-oxazolidinone

: 113453-30-8
(2S,3R,4E)-N-methoxy-N,2-dimethyl-5-phenyl-3-<(phenylmethoxy)methoxy>-4-pentenamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) AlMe₃ / 1) CH₂Cl₂, 30 min, room temp., toluene; 2) CH₂Cl₂, 0-10 deg C

2: 94 percent / i-Pr₂EtN, Bu₄NI / tetrahydrofuran / 38 h / Ambient temperature

With trimethylaluminum; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ja00216a026