(2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

Base Information

Chemical Name:(2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol
CAS No.:1238894-98-8
Molecular Formula:C₂₃H₂₄N₂O
Molecular Weight:344.456
Hs Code.:

Synonyms:(2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

Suppliers and Price of (2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

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Technology Process of (2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

There total 1 articles about (2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1238894-90-0
C₁₄H₁₄N₂O

: 4392-24-9
Cinnamyl bromide

: (2R)-2-phenyl-2-{[(1S,2S)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

: 1238894-98-8
(2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

Guidance literature:: With cerium(III) chloride heptahydrate; zinc; In tetrahydrofuran; at 20 ℃; for 4h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201000255

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1238894-98-8
(2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol

: 1238895-29-8
tert-butyl [(1R,2R)-2-phenyl-1-(3-pyridyl)but-3-enyl]carbamate

Guidance literature:: (2R)-2-phenyl-2-{[(1R,2R)-2-phenyl-1-(pyridin-3-yl)but-3-en-1-yl]amino}ethanol; With methanol; lead(IV) tetraacetate; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With hydroxylamine hydrochloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201000255