Technology Process of [(2R,3R,4R,5R,6R)-1,3-bis(benzyloxy)-2,4,6-trimethylnonan-5-yloxy]-tert-butyldimethylsilane
There total 10 articles about [(2R,3R,4R,5R,6R)-1,3-bis(benzyloxy)-2,4,6-trimethylnonan-5-yloxy]-tert-butyldimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethylmagnesium bromide;
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran;
for 1h;
Inert atmosphere;
(2R,3R,4S,5R,6R)-5,7-bis(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyl 4-methylbenzenesulfonate;
In
tetrahydrofuran;
at -20 - 20 ℃;
for 5h;
chemoselective reaction;
Inert atmosphere;
DOI:10.1055/s-0032-1316561
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.25 h / Inert atmosphere
1.2: 0 °C
2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
3.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 1 h / Inert atmosphere
3.2: 5 h / -20 - 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; copper(I) bromide dimethylsulfide complex; di(n-butyl)tin oxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0032-1316561
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: camphor-10-sulfonic acid / methanol / 3 h / 20 °C / Inert atmosphere
2.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.25 h / Inert atmosphere
2.2: 0 °C
3.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 1 h / Inert atmosphere
4.2: 5 h / -20 - 20 °C / Inert atmosphere
With
2,6-dimethylpyridine; copper(I) bromide dimethylsulfide complex; camphor-10-sulfonic acid; di(n-butyl)tin oxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-0032-1316561
