Met-enkephalinamide

Base Information

• Chemical Name: Met-enkephalinamide
• CAS No.: 60117-17-1
• Molecular Formula: C27H36N6O6S
• Molecular Weight: 572.685
• DSSTox Substance ID: DTXSID00975547
• Nikkaji Number: J532.086K
• Wikidata: Q82960180
• ChEMBL ID: CHEMBL247368
• Mol file: 60117-17-1.mol

Synonyms:enkephalinamide-Met-;Met-enkephalinamide;methionine enkephalinamide

Chemical Property of Met-enkephalinamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 142-145 °C
• Boiling Point: 1066.7°C at 760 mmHg
• PKA: 9.97±0.15(Predicted)
• Flash Point: 598.9°C
• PSA: 231.04000
• Density: 1.303g/cm³
• LogP: 1.90930
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 16
• Exact Mass: 572.24170406
• Heavy Atom Count: 40
• Complexity: 847

Purity/Quality:

98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSCCC(C(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
• Isomeric SMILES: CSCC[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N

Technology Process of Met-enkephalinamide

There total 3 articles about Met-enkephalinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Tyr-Gly-Gly-Phe-Met-NH2*HCOOH (84969-61-9) → 5-enkephalin (60117-17-1)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.5h;

Reference yield: 32.0%

C12H16NO4S(1+)*BF4(1-) + Pms-Met-OH + C19H22NO4S(1+)*BF4(1-) + C19H22NO5S(1+)*BF4(1-) → 5-enkephalin (60117-17-1)

Guidance literature:

Multistep reaction.;

DOI:10.1016/j.tet.2003.12.036

Reference yield:

→ 5-enkephalin (60117-17-1)

Guidance literature:

With hydrogen fluoride; methoxybenzene; at 0 ℃; for 1h; Yield given;

upstream raw materials:

Tyr-Gly-Gly-Phe-Met-NH₂*HCOOH

Refernces

• 1、 Hojo, Keiko,Maeda, Mitsuko,Kawasaki, Koichi. "Solid-phase peptide synthesis in water. Part 3: A water-soluble N-protecting group, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl tetrafluoroborate, and its application to solid phase peptide synthesis in water". . p. 1875 - 1886. Retrieved 2007/10/03.
• 2、 Bello, Carlo Di,Lucchiari, Adriana,Buso, Orfeo. "SOLID-PHASE SYNTHETIC ROUTES TO ENKEPHALIN DERIVATIVES". . p. 617 - 620. Retrieved 2007/10/02.