11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one

Base Information

• Chemical Name: 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one
• CAS No.: 1491132-45-6
• Molecular Formula: C₂₂H₂₂BrNO₄
• Molecular Weight: 444.325

Synonyms:11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one

Chemical Property of 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one

There total 4 articles about 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) + 1-(2-bromobenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline (80041-81-2) → 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one (1491132-45-6)

Guidance literature:

With triethylamine; In toluene; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.08.013

Reference yield:

2-bromophenylacetyl chloride (55116-09-1) → 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one (1491132-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere

3: triethylamine / toluene / 3 h / Reflux; Inert atmosphere

With triethylamine; sodium hydroxide; trichlorophosphate; In dichloromethane; water; toluene; acetonitrile; 1: |Bischler-Napieralski Reaction / 2: |Bischler-Napieralski Reaction;

DOI:10.1016/j.ejmech.2013.08.013

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one (1491132-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 1 h / Reflux; Inert atmosphere

3: triethylamine / toluene / 3 h / Reflux; Inert atmosphere

With triethylamine; sodium hydroxide; trichlorophosphate; In dichloromethane; water; toluene; acetonitrile; 1: |Bischler-Napieralski Reaction / 2: |Bischler-Napieralski Reaction;

DOI:10.1016/j.ejmech.2013.08.013

upstream raw materials:

2,2,6-trimethyl-4H-1,3-dioxin-4-one

1-(2-bromobenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline

2-bromophenylacetyl chloride

β-(3,4-dimethoxyphenyl)ethyl-(2'-bromophenyl)acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1491132-45-6 11B-(2-bromobenzyl)-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send