5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Base Information

Chemical Name:5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine
CAS No.:1572927-57-1
Molecular Formula:C₂₀H₂₅N₅O₃S₂
Molecular Weight:447.582
Hs Code.:

Synonyms:5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Chemical Property of 5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Chemical Property:

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Technology Process of 5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

There total 15 articles about 5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-18-7
tert-butyl (5-(((3S)-4-(4-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572927-56-0
5-(((3S)-4-(4-(S)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-57-1
5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Overall yield = 60 mg;

Reference yield:

: 104-95-0
(4-bromophenyl)thioanisole

: 1572927-56-0
5-(((3S)-4-(4-(S)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-57-1
5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dihydrogen peroxide; acetic acid / water / 0 - 20 °C

2.1: sodium azide / chloroform / 20 °C

2.2: 0 - 20 °C

3.1: formic acid; sulfuric acid / water / 36 h / 20 - 100 °C

4.1: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

5.1: sulfuric acid / chloroform / 1 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; formic acid; sodium azide; sulfuric acid; dihydrogen peroxide; acetic acid; triethylamine; trifluoroacetic acid; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane; chloroform; water;

Reference yield:

: 1450620-13-9
benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1572927-56-0
5-(((3S)-4-(4-(S)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

: 1572927-57-1
5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

2: sulfuric acid / chloroform / 1 h / 20 °C / Cooling with ice

3: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; triethylamine; trifluoroacetic acid; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane; chloroform;