2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Base Information

Chemical Name:2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide
CAS No.:936552-44-2
Molecular Formula:C₁₇H₂₇NO₄Si
Molecular Weight:337.491
Hs Code.:

Synonyms:2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Suppliers and Price of 2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

There total 6 articles about 2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 875926-27-5
2-(tert-butyldimethylsilyloxy)-4-methoxy-N,N-dimethylbenzamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 936552-44-2
2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Guidance literature:: 2-(tert-butyldimethylsilyloxy)-4-methoxy-N,N-dimethylbenzamide; With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 2h;

N,N-dimethyl-formamide; In tetrahydrofuran; pentane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/ja0685708

Reference yield:

: 2237-36-7
4-methoxysalicylic acid

: 936552-44-2
2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (COCl)2 / dimethylformamide / CH₂Cl₂ / 2 h / 0 - 20 °C

2.1: Et₃N / CH₂Cl₂ / 8 h / 0 - 20 °C

3.1: 8.75 g / Et₃N / 4-dimethylaminopyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: N,N,N',N'-tetramethylethylenediamine; t-BuLi / tetrahydrofuran; pentane / 2 h / -78 °C

4.2: 88 percent / tetrahydrofuran; pentane / -78 - 20 °C

With oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; triethylamine; dmap; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ja0685708

Reference yield:

: 15198-08-0
2-hydroxy-4-methoxybenzoyl chloride

: 936552-44-2
2-(tert-butyldimethylsilyloxy)-6-formyl-4-methoxy-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂ / 8 h / 0 - 20 °C

2.1: 8.75 g / Et₃N / 4-dimethylaminopyridine / CH₂Cl₂ / 12 h / 20 °C

3.1: N,N,N',N'-tetramethylethylenediamine; t-BuLi / tetrahydrofuran; pentane / 2 h / -78 °C

3.2: 88 percent / tetrahydrofuran; pentane / -78 - 20 °C

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; triethylamine; dmap; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ja0685708