N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol

Base Information

• Chemical Name: N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol
• CAS No.: 468773-20-8
• Molecular Formula: C₁₇H₂₆N₂O₅S
• Molecular Weight: 370.47
• Mol file: 468773-20-8.mol

Synonyms:N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol

Chemical Property of N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol

There total 4 articles about N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-Methyl-2-[(4-methyl-pent-3-enyl)-(2-nitro-benzenesulfonyl)-amino]-butyric acid methyl ester → N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol (468773-20-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(02)00242-9

Reference yield:

L-valine methylester hydrochloride (6306-52-1) → N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol (468773-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2: Cs₂CO₃ / dimethylformamide / 16 h / 60 °C

3: 2.1 g / LAH / tetrahydrofuran / 0.5 h / 0 °C

With lithium aluminium tetrahydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00242-9

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinol (468773-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2: Cs₂CO₃ / dimethylformamide / 16 h / 60 °C

3: 2.1 g / LAH / tetrahydrofuran / 0.5 h / 0 °C

With lithium aluminium tetrahydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00242-9

upstream raw materials:

L-valine methylester hydrochloride

2-Nitrobenzenesulfonyl chloride

methyl (S)-3-methyl-2-(2-nitrophenylsulfonamido)butanoate

Downstream raw materials:

7-isopropyl-1,3,3-methyl-6-(2-nitrobenzenesulfonyl)-octahydro-isoxazolo[3,4-c]pyridine

N-(4-methylpent-3-enyl)-N-(2-nitrobenzenesulfonyl)-(S)-valinal