4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

Base Information

Chemical Name:4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate
CAS No.:1245077-63-7
Molecular Formula:C₇H₈O₃S*C₂₆H₃₁F₂N₇O₄
Molecular Weight:715.778
Hs Code.:

4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

Synonyms:4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

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Chemical Property of 4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

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Technology Process of 4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

There total 1 articles about 4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245079-56-4
4-(5-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

: 104-15-4
toluene-4-sulfonic acid

: 1245077-63-7
4-(5-{2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate

Guidance literature:: 4-(5-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yl}-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

With sodium carbonate; In dichloromethane;

toluene-4-sulfonic acid; In methanol;