N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

Base Information

Chemical Name:N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine
CAS No.:288582-48-9
Molecular Formula:C₅₅H₆₃N₃O₅Si
Molecular Weight:874.208
Hs Code.:

N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

Synonyms:N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

There total 5 articles about N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 288582-47-8
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-hydroxypropylamine

: 288582-48-9
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo000071g

Reference yield:

: 89813-47-8
N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester

: 288582-48-9
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine; (CF₃SO₂)2O / CH₂Cl₂ / 1 h / -30 °C

1.2: 68 percent / diisopropylethylamine / CH₂Cl₂ / 76 h / -10 °C

2.1: 93 percent / Et₃N; DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; trifluoromethylsulfonic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.1: sulfonation / 1.2: Substitution / 2.1: silylation;
DOI:10.1021/jo000071g

Reference yield:

: 13515-76-9,116457-91-1,4465-44-5
methyl N-trityl-L-serinate

: 288582-48-9
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2S)-triphenylmethylamino-3-(tert-butyldiphenylsilyloxy)propylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / HN₃; PPh₃; DEAD / benzene / 0.25 h / 20 °C

2.1: 77 percent / LiAlH₄ / diethyl ether / 2 h / Heating

3.1: diisopropylethylamine; (CF₃SO₂)2O / CH₂Cl₂ / 1 h / -30 °C

3.2: 68 percent / diisopropylethylamine / CH₂Cl₂ / 76 h / -10 °C

4.1: 93 percent / Et₃N; DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; trifluoromethylsulfonic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In diethyl ether; dichloromethane; benzene; 1.1: Substitution / 2.1: Reduction / 3.1: sulfonation / 3.2: Substitution / 4.1: silylation;
DOI:10.1021/jo000071g