tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

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Chemical Name:tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate
CAS No.:442851-51-6
Molecular Formula:C₄₄H₄₇FN₂O₅
Molecular Weight:702.866
Hs Code.:

Synonyms:tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

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Chemical Property of tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

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Technology Process of tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

There total 5 articles about tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447820-23-6
C₁₈H₂₇NO₄

: 125971-96-2,125971-58-6
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

: 442851-51-6
tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

Guidance literature:: With Trimethylacetic acid; In tetrahydrofuran; n-heptane; toluene; at 110 ℃; for 26h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201204609

Reference yield:

: 1447820-18-9
(R)-5-(diallylamino)pentane-1,3-diol

: 442851-51-6
tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / toluene / 14 h / Inert atmosphere; Reflux

2: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; Thiosalicylic acid / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

4: Trimethylacetic acid / tetrahydrofuran; toluene; n-heptane / 26 h / 110 °C / Inert atmosphere

With manganese(IV) oxide; potassium tert-butylate; Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; Trimethylacetic acid; In tetrahydrofuran; n-heptane; toluene;
DOI:10.1002/chem.201204609

Reference yield:

: 1447820-21-4
C₃₀H₃₅NO₂

: 442851-51-6
tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: rochelle salt / water / 2.5 h / 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / toluene / 14 h / Inert atmosphere; Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

4.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; Thiosalicylic acid / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

5.1: Trimethylacetic acid / tetrahydrofuran; toluene; n-heptane / 26 h / 110 °C / Inert atmosphere

With manganese(IV) oxide; potassium tert-butylate; Thiosalicylic acid; rochelle salt; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; Trimethylacetic acid; In tetrahydrofuran; n-heptane; water; toluene;
DOI:10.1002/chem.201204609