(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Base Information

Chemical Name:(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone
CAS No.:762245-24-9
Molecular Formula:C₂₉H₃₄N₂O₃S₂
Molecular Weight:522.733
Hs Code.:

(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl]-methanone

Synonyms:(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

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Chemical Property of (2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

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Technology Process of (2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

There total 11 articles about (2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 762245-23-8
(4-benzyloxy-5-methoxy-2-nitro-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

: 762245-24-9
(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Guidance literature:: With tin(ll) chloride; In methanol; for 2.5h; Heating;
DOI:10.1016/j.bmcl.2004.07.001

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 762245-24-9
(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / Et₃N / tetrahydrofuran / 4 h

2: 88 percent / LiBH₄ / tetrahydrofuran; methanol / 6 h

3: 81 percent / IBX / dimethylsulfoxide / 6 h

4: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 18 h

5: 76 percent / SnCl₂*2H₂O / methanol / 2.5 h / Heating

With lithium borohydride; boron trifluoride diethyl etherate; triethylamine; tin(ll) chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.07.001

Reference yield:

: 74163-81-8
L-Tic-OH

: 762245-24-9
(2-amino-4-benzyloxy-5-methoxy-phenyl)-[3-(bis-ethylsulfanyl-methyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / aq.NaOH / 36 h

2: 96 percent / SOCl₂ / 6 h / Heating

3: 75 percent / TMSI / acetonitrile / 4 h

4: 60 percent / Et₃N / tetrahydrofuran / 4 h

5: 88 percent / LiBH₄ / tetrahydrofuran; methanol / 6 h

6: 81 percent / IBX / dimethylsulfoxide / 6 h

7: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 18 h

8: 76 percent / SnCl₂*2H₂O / methanol / 2.5 h / Heating

With sodium hydroxide; lithium borohydride; thionyl chloride; trimethylsilyl iodide; boron trifluoride diethyl etherate; triethylamine; tin(ll) chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmcl.2004.07.001