3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Base Information

Chemical Name:3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate
CAS No.:1225377-65-0
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Suppliers and Price of 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

There total 6 articles about 3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225377-61-6
3-((1R,2S,4R)-2-(cyanomethyl)-4-methyl-6-oxocyclohexyl)propyl acetate

: 1225377-65-0
3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; toluene / 0.58 h / 23 °C / Inert atmosphere

2: magnesium(II) perchlorate / 0.5 h / 23 °C / Inert atmosphere

With magnesium(II) perchlorate; In tetrahydrofuran; toluene;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-59-2
(R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propyl acetate

: 1225377-65-0
3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.68 h / -78 °C / Inert atmosphere

1.2: 0.55 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran; toluene / 0.58 h / 23 °C / Inert atmosphere

3.1: magnesium(II) perchlorate / 0.5 h / 23 °C / Inert atmosphere

With n-butyllithium; magnesium(II) perchlorate; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1021/jo400695c

Reference yield:

: 89-82-7,90449-51-7
pulegone

: 1225377-65-0
3-((1R,2S,4R,6S)-2-acetoxy-6-(cyanomethyl)-2-ethynyl-4-methylcyclohexyl)propyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide; water / methanol / 23 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 66 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.08 h / 0 °C / Inert atmosphere

3.2: 70 h / 23 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 11 h / -78 - 23 °C / Inert atmosphere

5.1: n-butyllithium / diethyl ether; hexane / 0.68 h / -78 °C / Inert atmosphere

5.2: 0.55 h / -78 °C / Inert atmosphere

6.1: tetrahydrofuran; toluene / 0.58 h / 23 °C / Inert atmosphere

7.1: magnesium(II) perchlorate / 0.5 h / 23 °C / Inert atmosphere

With n-butyllithium; magnesium(II) perchlorate; water; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jo400695c