N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

Base Information

Chemical Name:N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine
CAS No.:1334106-35-2
Molecular Formula:C₃₀H₃₉N₃O
Molecular Weight:457.659
Hs Code.:

Synonyms:N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

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Chemical Property of N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

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Technology Process of N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

There total 6 articles about N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1334106-46-5
1-benzyl-4-(4-chlorobutyl)piperidine

: 130081-94-6
5-hydroxy-N-[(1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine

: 1334106-35-2
N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 70 ℃;
DOI:10.1021/jm200853t

Reference yield:

: 141359-47-9
C₁₈H₂₃NO₂

: 1334106-35-2
N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

2: triethylamine / dichloromethane

3: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

4: thionyl chloride / dichloromethane / 2 h / Cooling with ice; Reflux

5: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 - 70 °C

With lithium aluminium tetrahydride; thionyl chloride; palladium on activated charcoal; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200853t

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1334106-35-2
N-{[5-(4-(1-benzylpiperidin-4-yl)butoxy)-1-methyl-1H-indol-2-yl]methyl}-N-methylprop-2-yn-1-amine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / ethanol / Reflux

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

3: triethylamine / dichloromethane

4: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

5: thionyl chloride / dichloromethane / 2 h / Cooling with ice; Reflux

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 - 70 °C

With lithium aluminium tetrahydride; thionyl chloride; palladium on activated charcoal; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200853t