(R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate

Base Information

• Chemical Name: (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate
• CAS No.: 1228391-42-1
• Molecular Formula: C₁₀H₁₃N₃*C₁₈H₁₄O₈
• Molecular Weight: 533.538
• Mol file: 1228391-42-1.mol

Synonyms:(R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate

Chemical Property of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate

There total 2 articles about (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine (753015-44-0) + O,O'-dibenzoyl-D-tartaric acid (17026-42-5) → (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate (1228391-42-1)

Guidance literature:

In ethanol; at 20 ℃; Heating;

Reference yield:

(R)-3-vinylpyrrolidine-1-carboxylic acid t-butyl ester (1228312-14-8) → (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-di-benzoyl-D-tartarate (1228391-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium acetate / palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 16 h / 150 °C / Inert atmosphere

1.2: 1.5 h / 20 - 23 °C

2.1: ethanol / Heating

With sodium acetate; 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; In ethanol; N,N-dimethyl acetamide;

upstream raw materials:

(R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine

O,O'-dibenzoyl-D-tartaric acid

(R)-3-vinylpyrrolidine-1-carboxylic acid t-butyl ester