N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Base Information

Chemical Name:N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride
CAS No.:1109230-10-5
Molecular Formula:C₃₃H₃₄F₅N₃O₄*ClH
Molecular Weight:668.104
Hs Code.:

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Synonyms:N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

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Chemical Property of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

There total 8 articles about N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1109230-04-7
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

: 1109230-10-5
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; Inert atmosphere;

Reference yield:

: 1109230-05-8
2-(2-bromophenyl)-N-(2-ethoxyethyl)ethanamine

: 1109230-10-5
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 20 h / 0 - 20 °C / Inert atmosphere

2.1: dmap; trifluoromethylsulfonic anhydride / dichloromethane / 49.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 h / 20 °C

4.1: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 24 h / 20 - 100 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; trifluoromethylsulfonic anhydride; water; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1109230-07-0
5-bromo-2-(2-hydroxyethyl)-3,4-dihydroisoquinolin-1(2H)-one

: 1109230-10-5
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 °C

2.1: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 24 h / 20 - 100 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C / Inert atmosphere

With hydrogenchloride; water; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; potassium hydroxide; palladium diacetate; triphenylphosphine; In 1,4-dioxane; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;