[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester
CAS No.:928664-02-2
Molecular Formula:C₂₇H₃₄F₂N₂O₄S₃
Molecular Weight:584.773
Hs Code.:

[{4-[<i>tert</i>-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

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Chemical Property of [{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

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Technology Process of [{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

There total 1 articles about [{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 928664-01-1
2,4-Bis-[amino-(4-fluorophenyl)-methyl]-[1,3,5]trithiane

: 24424-99-5
di-tert-butyl dicarbonate

: 928664-02-2
[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: In dichloromethane;
DOI:10.1021/ol0700153

Reference yield:

: 928664-02-2
[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

: 928664-04-4
N-(6-amino-pyridin-2-yl)-N'-[{4-[[3-(6-amino-pyridin-2-ylcarbamoyl)-propionylamino]-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: DCC; N-hydroxy succinimide; DMAP / CH₂Cl₂ / 1 h

2: trifluoroacetic acid / CH₂Cl₂

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol0700153

Reference yield:

: 928664-02-2
[{4-[tert-butoxycarbonylamino-(4-fluoro-phenyl)-methyl]-[1,3,5]trithian-2-yl}-(4-fluoro-phenyl)-methyl]-carbamic acid tert-butyl ester

: C₄₃H₃₈F₂N₈O₆S₃

Guidance literature:: Multi-step reaction with 4 steps

1: DCC; N-hydroxy succinimide; DMAP / CH₂Cl₂ / 1 h

2: trifluoroacetic acid / CH₂Cl₂

3: Et₃N / dimethylformamide; tetrahydrofuran / 12 h

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0700153