(R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

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Chemical Name:(R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate
CAS No.:1218932-35-4
Molecular Formula:C₂₅H₂₆F₂N₂O₅S
Molecular Weight:504.555
Hs Code.:

Synonyms:(R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

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Chemical Property of (R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

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Technology Process of (R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

There total 1 articles about (R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1218932-33-2
(R)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate

: 1218932-35-4
(R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

Guidance literature:: (R)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With Glauber's salt; In tetrahydrofuran; at 0 ℃;

Reference yield: 79.0%

: 1218932-35-4
(R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate

: 1218932-36-5
(R)-N-(3-(1-amino-2-hydroxyethyl)phenyl)-2',4'-difluorobiphenyl-4-sulfonamide

Guidance literature:: (R)-tert-butyl 1-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)-2-hydroxyethylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In methanol; dichloromethane;