(3S)-4-(4-aminophenyl)-3-({alpha-methyl-N-[(tricyclo[3.3.1.1~3,7~]dec-2-yloxy)carbonyl]-D-tryptophyl}amino)butanoic acid

Base Information

Chemical Name:(3S)-4-(4-aminophenyl)-3-({alpha-methyl-N-[(tricyclo[3.3.1.1~3,7~]dec-2-yloxy)carbonyl]-D-tryptophyl}amino)butanoic acid
CAS No.:149027-97-4
Molecular Formula:C33H40 N4 O5
Molecular Weight:572.6945
Hs Code.:

Synonyms:Benzenebutanoicacid, 4-amino-b-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-,[R-(R*,S*)]- (9CI); PD 140376

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-4-(4-aminophenyl)-3-({alpha-methyl-N-[(tricyclo[3.3.1.1~3,7~]dec-2-yloxy)carbonyl]-D-tryptophyl}amino)butanoic acid

Chemical Property:

Vapor Pressure:3.84E-33mmHg at 25°C
Boiling Point:879.8°C at 760 mmHg
Flash Point:485.9°C
Density:1.32g/cm³

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S)-4-(4-aminophenyl)-3-({alpha-methyl-N-[(tricyclo[3.3.1.1~3,7~]dec-2-yloxy)carbonyl]-D-tryptophyl}amino)butanoic acid

There total 6 articles about (3S)-4-(4-aminophenyl)-3-({alpha-methyl-N-[(tricyclo[3.3.1.1~3,7~]dec-2-yloxy)carbonyl]-D-tryptophyl}amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159630-66-7
(S)-3-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-(4-nitro-phenyl)-butyric acid

: 149027-97-4
[3H]-PD 140376

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; under 2068.6 Torr;
DOI:10.1016/0968-0896(96)00185-X

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 149027-97-4
[3H]-PD 140376

Guidance literature:: Multi-step reaction with 8 steps

1: aq. NaOH, NaHCO₃ / dioxane / 0 - 20 °C

2: N-methyl morpholine / tetrahydrofuran

3: diethyl ether / 0 - 20 °C

4: silver benzoate, Et₃N

5: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

6: 1.) 1-hydroxybenzotriazole, 1,3-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2.) EtOAc, RT

7: tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

8: H₂ / Pd(OH)2 / ethanol / 2068.6 Torr

With 4-methyl-morpholine; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen; silver benzoate; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/0968-0896(96)00185-X

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 149027-97-4
[3H]-PD 140376

Guidance literature:: Multi-step reaction with 7 steps

1: N-methyl morpholine / tetrahydrofuran

2: diethyl ether / 0 - 20 °C

3: silver benzoate, Et₃N

4: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

5: 1.) 1-hydroxybenzotriazole, 1,3-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2.) EtOAc, RT

6: tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

7: H₂ / Pd(OH)2 / ethanol / 2068.6 Torr

With 4-methyl-morpholine; tetrabutyl ammonium fluoride; hydrogen; silver benzoate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/0968-0896(96)00185-X