7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene

Base Information

• Chemical Name: 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene
• CAS No.: 163300-19-4
• Molecular Formula: C₂₂H₂₁ClN₂O₄S
• Molecular Weight: 444.939
• Mol file: 163300-19-4.mol

Synonyms:7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene

Chemical Property of 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene

There total 2 articles about 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-tert-butyloxycarbonyl-pyrrole (5176-27-2) + phenylsulfonyl 6-chloro-3-pyridyl acetylene (152328-56-8) → 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene (163300-19-4)

Guidance literature:

at 80 - 85 ℃; for 24h;

DOI:10.1080/00397919508010790

Reference yield: 64.0%

N-carbo-t-butoxy pyrrole (N-t-Boc-pyrrole) + 7-carbomethoxy-2-(2-methoxypyridyl)-7-aza-bicyclo[2.2.1]heptane + phenylsulfonyl 6-chloro-3-pyridyl acetylene (152328-56-8) → 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene (163300-19-4)

Guidance literature:

Reference yield: 96.0%

7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2,5-diene (163300-19-4) → 7-(tert-butoxycarbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo<2.2.1>heptane-2-ene

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; nickel(II) acetate ⁽¹⁺⁾; In tetrahydrofuran; ethanol; water; for 1h;

DOI:10.1080/00397919508010790

upstream raw materials:

N-tert-butyloxycarbonyl-pyrrole

phenylsulfonyl 6-chloro-3-pyridyl acetylene