4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

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Chemical Name:4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate
CAS No.:85768-32-7
Molecular Formula:C₂₈H₃₁ClN₂O₈S₂
Molecular Weight:623.148
Hs Code.:

Synonyms:4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

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Chemical Property of 4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

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Technology Process of 4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

There total 5 articles about 4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 85768-31-6
4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio propenoate

: 85768-32-7
4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 25 ℃;
DOI:10.1039/c39830001005

Reference yield:

: 937-64-4
4-chlorophenyl chlorothionoformate

: 85768-32-7
4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) base, 2.) LiN(SiMe₃)2 / 2.) -78 deg C to room temp.

2: 50 percent / -40 - 20 °C

3: 50 percent / 0.6 M HCl / H₂O; tetrahydrofuran / 25 °C

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1039/c39830001005

Reference yield:

: 85768-12-3
4-nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-ethylthio-azetidin-2-on-1-yl]-acetate

: 85768-32-7
4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) base, 2.) LiN(SiMe₃)2 / 2.) -78 deg C to room temp.

2: 50 percent / -40 - 20 °C

3: 50 percent / 0.6 M HCl / H₂O; tetrahydrofuran / 25 °C

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1039/c39830001005