4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

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Chemical Name:4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine
CAS No.:103409-70-7
Molecular Formula:C₂₉H₂₆F₂N₂O
Molecular Weight:456.535
Hs Code.:

Synonyms:4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

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Chemical Property of 4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

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Technology Process of 4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

There total 6 articles about 4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 64630-50-8
5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine-3-carboxaldehyde

: 64630-52-0
4,4-bis-(4-fluoro-phenyl)-butylamine

: 103409-70-7
4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

Guidance literature:: With 3 A molecular sieve; In cyclohexane; benzene; at 80 ℃; for 96h;
DOI:10.1002/jhet.5570220429

Reference yield:

: 64630-49-5
5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

: 103409-70-7
4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) POCl₃ / 1) room temp., 15 min; 2) 1,2-dichloroethane, reflux, 3 h

2: 92 percent / molecular sieves (3A) / benzene; cyclohexane / 96 h / 80 °C

With 3 A molecular sieve; trichlorophosphate; In cyclohexane; benzene;
DOI:10.1002/jhet.5570220429

Reference yield:

: 63880-57-9
1-[(2-fluorophenyl)methyl]pyrrole-2-carboxaldehyde

: 103409-70-7
4-fluoro-δ-(4-fluorophenyl)-N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzenebutanamine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaBH₄ / propan-2-ol / 20 h / 80 °C

2: 7 g / NaH / 1) benzene, reflux, 1 h; 2) DMF, 80 deg C, 6 h

3: 1) POCl₃ / 1) room temp., 15 min; 2) 1,2-dichloroethane, reflux, 3 h

4: 92 percent / molecular sieves (3A) / benzene; cyclohexane / 96 h / 80 °C

With sodium tetrahydroborate; 3 A molecular sieve; sodium hydride; trichlorophosphate; In cyclohexane; isopropyl alcohol; benzene;
DOI:10.1002/jhet.5570220429