Technology Process of 5-(3-(2-(1,3-dihydroxypropan-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride
There total 10 articles about 5-(3-(2-(1,3-dihydroxypropan-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol; diethyl ether;
at 20 ℃;
for 0.0833333h;
DOI:10.1021/jm200609t
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation
2: triethylamine / dichloromethane / 1 h / 20 °C
3: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 80 °C
4: pyridine / toluene / 2.33 h / 120 °C / Inert atmosphere
5: dichloromethane / 16 h / 0 - 20 °C
6: sodium tris(acetoxy)borohydride / dichloromethane / 19 h / 20 °C / Inert atmosphere
7: hydrogenchloride / tetrahydrofuran; water / 1.33 h / 20 °C / Inert atmosphere
8: hydrogenchloride / methanol; diethyl ether / 0.08 h / 20 °C
With
pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); hydroxylamine hydrochloride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200609t
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C
2: pyridine / toluene / 2.33 h / 120 °C / Inert atmosphere
3: dichloromethane / 16 h / 0 - 20 °C
4: sodium tris(acetoxy)borohydride / dichloromethane / 19 h / 20 °C / Inert atmosphere
5: hydrogenchloride / tetrahydrofuran; water / 1.33 h / 20 °C / Inert atmosphere
6: hydrogenchloride / methanol; diethyl ether / 0.08 h / 20 °C
With
pyridine; hydrogenchloride; oxalyl dichloride; sodium tris(acetoxy)borohydride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200609t