Technology Process of 3,3′-(1H,1′H-(6,6′-biindole)-1,1′-diylbis(methylene))dibenzoic acid
There total 9 articles about 3,3′-(1H,1′H-(6,6′-biindole)-1,1′-diylbis(methylene))dibenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1H,1′H-6,6′-biindole;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
3-methoxycarbonylbenzyl bromide;
at 0 - 20 ℃;
for 1h;
With
sodium hydroxide;
for 1h;
DOI:10.1039/c6ob01334a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 4 h / Inert atmosphere; Reflux
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C
4.2: 20 °C
5.1: sodium hydroxide; water / 1 h
With
tetrakis(triphenylphosphine) palladium(0); water; sodium hydride; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500344y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.2: 1 h / 0 - 20 °C
2.3: 1 h
With
dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium hydride; potassium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: |Suzuki-Miyaura Coupling;
DOI:10.1039/c6ob01334a
