(3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Base Information

Chemical Name:(3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole
CAS No.:886969-05-7
Molecular Formula:C₁₈H₂₁N₃O₅
Molecular Weight:359.382
Hs Code.:

Synonyms:(3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

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Chemical Property of (3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

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Technology Process of (3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

There total 4 articles about (3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 886969-01-3
1-bromomethyl-2-prop-2-ynyloxy-benzene

: 4711-03-9
5-azido-5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose

: 886969-05-7
(3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 ℃; for 12h;
DOI:10.1016/j.tetlet.2006.02.068

Reference yield:

: 89-95-2
2-methyl-benzyl alcohol

: 886969-05-7
(3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / PBr₃ / diethyl ether / 2 h / 25 °C

2: 71 percent / NaH / tetrahydrofuran / 12 h / 25 °C

With phosphorus tribromide; sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tetlet.2006.02.068

Reference yield:

: 29978-83-4
o-propargyloxybenzaldehyde

: 886969-05-7
(3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaBH₄; NaOH / 6 h / 25 °C

2: 91 percent / PBr₃ / diethyl ether / 2 h / 25 °C

3: 71 percent / NaH / tetrahydrofuran / 12 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; phosphorus tribromide; sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tetlet.2006.02.068