((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester
• CAS No.: 607742-48-3
• Molecular Formula: C₁₈H₁₉NO₅
• Molecular Weight: 329.353
• Mol file: 607742-48-3.mol

Synonyms:((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester

Chemical Property of ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester

There total 3 articles about ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

benzyl chloroformate (501-53-1,94274-21-2) + (-)-(S)-3,4-methylenedioxyphenylalaninol (607742-47-2) → ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester (607742-48-3)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; at 20 ℃; for 24h;

DOI:10.1016/S0957-4166(03)00458-0

Reference yield:

ethyl (R)-2-amino-3-(3,4-methylenedioxyphenyl)propionate (607742-46-1) → ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester (607742-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / LiAlH₄ / diethyl ether / 24 h / 20 °C

2: 24 percent / K₂CO₃ / ethyl acetate; H₂O / 24 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; water; ethyl acetate;

DOI:10.1016/S0957-4166(03)00458-0

Reference yield:

(R)-2-Amino-3-benzo[1,3]dioxol-5-yl-propionic acid; hydrochloride (77141-01-6) → ((R)-2-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-ethyl)-carbamic acid benzyl ester (607742-48-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / SOCl₂ / 3 h / Heating

2: 50 percent / LiAlH₄ / diethyl ether / 24 h / 20 °C

3: 24 percent / K₂CO₃ / ethyl acetate; H₂O / 24 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In diethyl ether; water; ethyl acetate;

DOI:10.1016/S0957-4166(03)00458-0

upstream raw materials:

benzyl chloroformate

(-)-(S)-3,4-methylenedioxyphenylalaninol

ethyl (R)-2-amino-3-(3,4-methylenedioxyphenyl)propionate

(R)-2-Amino-3-benzo[1,3]dioxol-5-yl-propionic acid; hydrochloride