(4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole

Base Information

• Chemical Name: (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole
• CAS No.: 197232-60-3
• Molecular Formula: C₁₆H₁₉N₃O₃
• Molecular Weight: 301.345
• Mol file: 197232-60-3.mol

Synonyms:(4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole

Chemical Property of (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole

There total 3 articles about (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4R,5S,3'R)-1,5-dimethyl-3-[(1'-acetyl-2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one → (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole (197232-60-3)

Guidance literature:

In chloroform; for 20h; Product distribution; Ambient temperature; spontaneous ring expansion, various N-acyl aziridine 2-imides to oxazoline-4-imides; faster at reflux; also in toluene in presence of Amberlyst H-15 or BF₃*Et₂O;

DOI:10.1016/S0040-4039(97)01630-4

Reference yield: 71.0%

(4R,5S,3'R)-1,5-dimethyl-3-[(1'-acetyl-2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one → (4R,5S,3'R)-1,5-dimethyl-3-(2'-acetamido-3'-hydroxypropionyl)-4-phenylimidazolidin-2-one (197232-68-1) + (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole (197232-60-3)

Guidance literature:

With Amberlyst H-15; In toluene; for 6h; Heating;

DOI:10.1016/S0040-4039(97)01630-4

Reference yield:

(4R,5S,3'R)-1,5-dimethyl-3-[(1'-acetyl-2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one → (4R,4'R,5'S)-4,5-dihydro-2-methyl-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole (197232-60-3) + (5R,4'R,5'S)-4,5-dihydro-2-methyl-5-[(1,5-dimethyl-4-phenylimidazolidin-2'-on-3'-yl)carbonyl]oxazole

Guidance literature:

With magnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.166667h; microwave irradiation;

DOI:10.1016/S0040-4020(01)00123-5

Downstream raw materials:

(R)-2-acetamido-3-hydroxypropionic acid

(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one

(4R,5S,3'R)-1,5-dimethyl-3-(2'-acetamido-3'-hydroxypropionyl)-4-phenylimidazolidin-2-one