2-Oxazolidinone, 3-amino-5-(4-morpholinylmethyl)-

Base Information

• Chemical Name: 2-Oxazolidinone, 3-amino-5-(4-morpholinylmethyl)-
• CAS No.: 43056-63-9
• Molecular Formula: C8H15N3O3
• Molecular Weight: 201.225
• Hs Code.: 2934999090
• European Community (EC) Number: 256-068-9
• DSSTox Substance ID: DTXSID20962873
• Nikkaji Number: J598.241C
• Mol file: 43056-63-9.mol

Synonyms:3-amino-5-morpholinomethyl-2-oxazolidinone;AMOZ cpd

Chemical Property of 2-Oxazolidinone, 3-amino-5-(4-morpholinylmethyl)-

Chemical Property:

• Vapor Pressure: 0.000428mmHg at 25°C
• Melting Point: 115-120 °C
• Refractive Index: 1.536
• Boiling Point: 315.8 °C at 760 mmHg
• PKA: 6.19±0.10(Predicted)
• Flash Point: 144.8 °C
• PSA: 68.03000
• Density: 1.281 g/cm³
• LogP: -0.41080
• Storage Temp.: 0-6°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 201.11134135
• Heavy Atom Count: 14
• Complexity: 218

Purity/Quality:

98%Min ^*data from raw suppliers

AMOZ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC2CN(C(=O)O2)N
• Uses: A metabolite of Furaltadone Hydrochloride Environmental contaminants; Food contaminants; Heat processing contaminants.

Technology Process of 2-Oxazolidinone, 3-amino-5-(4-morpholinylmethyl)-

There total 7 articles about 2-Oxazolidinone, 3-amino-5-(4-morpholinylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-(morpholinomethyl)oxazolidin-2-one (17930-35-7) → 3-amino-5-(morpholinomethyl)oxazolidin-2-one (43056-63-9)

Guidance literature:

5-(morpholinomethyl)oxazolidin-2-one; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

With O-(diphenylphosphinyl)hydroxylamine; In N,N-dimethyl-formamide; at 80 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ol302201q

Reference yield: 8.6%

C13H23N3O5 → 3-amino-5-(morpholinomethyl)oxazolidin-2-one (43056-63-9)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 6h;

Reference yield:

furaltadone (139-91-3) → 3-amino-5-(morpholinomethyl)oxazolidin-2-one (43056-63-9)

Guidance literature:

With spring onion leaf/root bulb; at 25 ℃; for 12h;

DOI:10.1021/acs.jafc.7b01050

upstream raw materials:

5-(morpholinomethyl)oxazolidin-2-one

furaltadone

4-(oxiran-2-ylmethyl)morpholine

Downstream raw materials:

3-(5-nitro-1-methyl-2-imidazolyl)-methyleneamino-5-morpholinomethyl-2-oxazolidinone hydrochloride

3<<(2-Nitrophenyl)methylene>amino>-5-morpholinomethyl-2-oxazolidinone

(+/-)-3-<1-Methyl-5-nitro-imidazol-2-ylmethylen>-5-morpholinomethyl-oxazolidin-2-on

3-benzylideneamino-5-morpholin-4-ylmethyl-oxazolidin-2-one

Refernces

• 1、 Wang, Yinan,Chan, K. K. Jason,Chan, Wan. "Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil". . p. 4255 - 4261. Retrieved 2017/06/07.