4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Base Information

• Chemical Name: 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester
• CAS No.: 218916-26-8
• Molecular Formula: C₄₀H₄₇IO₆Si
• Molecular Weight: 778.8

Synonyms:4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Chemical Property of 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Chemical Property:

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Technology Process of 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

There total 2 articles about 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid (208941-37-1) → 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester (218916-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorenamine / CH₂Cl₂ / 3 h / Ambient temperature

2: Et₃N, pyridine, DMAP / CH₂Cl₂ / 21 h / Ambient temperature

With pyridine; dmap; chlorenamine; triethylamine; In dichloromethane;

DOI:10.1055/s-1998-1901

Reference yield:

5-(4-Chlorocarbonyl-phenoxy)-pentanoic acid tert-butyl ester + [4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-phenyl]-methanol (217462-60-7) → 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester (218916-26-8)

Guidance literature:

With pyridine; dmap; triethylamine; In dichloromethane; for 21h; Yield given; Ambient temperature;

DOI:10.1055/s-1998-1901

Reference yield: 99.0%

4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester (218916-26-8) → 4-(4-Carboxy-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester (218916-27-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 15h; Ambient temperature;

DOI:10.1055/s-1998-1901

upstream raw materials:

[4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-phenyl]-methanol

4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid

Downstream raw materials:

4-(4-Carboxy-butoxy)-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

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