3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

Base Information

• Chemical Name: 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide
• CAS No.: 1369885-77-7
• Molecular Formula: C₁₇H₁₃ClF₃N₅O₅S
• Molecular Weight: 491.835
• Mol file: 1369885-77-7.mol

Synonyms:3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

Chemical Property of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide

There total 2 articles about 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.6%

3-(2-chloro-3,3,3-trifluoroprop-1-en-yl)-2,2-dimethylcyclopropanecarboxylic acid (74609-46-4) + 5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-amine (109193-50-2) → 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide (1369885-77-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.3184/174751911X13230201951890

Reference yield:

3,5-dinitrobenzoic acid (99-34-3) → 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-(5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl)-2,2-dimethylcyclopropanecarboxamide (1369885-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.3184/174751911X13230201951890

upstream raw materials:

3-(2-chloro-3,3,3-trifluoroprop-1-en-yl)-2,2-dimethylcyclopropanecarboxylic acid

5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-amine

3,5-dinitrobenzoic acid