N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1044873-10-0
• Molecular Formula: C₂₂H₂₀F₃N₃O₃
• Molecular Weight: 431.414
• Mol file: 1044873-10-0.mol

Synonyms:N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property of N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride (2328-12-3) + 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (98534-81-7) → N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1044873-10-0)

Guidance literature:

With dmap; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 70h;

Reference yield: 96.0%

N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1044873-10-0) → N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (1044873-04-2)

Guidance literature:

N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 21.5h;

With methanol; In dichloromethane;

With sodium hydrogencarbonate; In methanol; at 20 ℃; for 0.5h;

upstream raw materials:

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Downstream raw materials:

N-(4-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-oyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline