Multi-step reaction with 8 steps
1.1: pyridinium p-toluenesulfonate / isopropyl alcohol; toluene / 28 - 80 °C / Inert atmosphere
2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C / Inert atmosphere
2.2: 13 h / -78 °C / Inert atmosphere
3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.1: dicobalt octacarbonyl / toluene / 1.5 h / 20 °C / Inert atmosphere
4.2: 12 h / 100 °C
5.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere
6.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
7.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere
7.2: 0 - 20 °C / Inert atmosphere
8.1: sodium hydrogencarbonate / 1,2-dichloro-benzene / 10 h / 170 °C / Inert atmosphere
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium borohydride; dicobalt octacarbonyl; borane-THF; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-benzene; isopropyl alcohol; toluene; mineral oil;
4.1: Pauson-Khand reaction / 4.2: Pauson-Khand reaction;
DOI:10.1002/anie.201103550