(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester

Base Information

• Chemical Name: (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester
• CAS No.: 61990-36-1
• Molecular Formula: C₁₇H₁₈N₂O₃S
• Molecular Weight: 330.408
• Mol file: 61990-36-1.mol

Synonyms:(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester

Chemical Property of (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester

There total 1 articles about (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6β-(phenylacetamido)penicillanate 1β-oxide (24652-72-0) → (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester (61990-36-1)

Guidance literature:

With phosphorous acid trimethyl ester; In benzene; for 28h; Heating;

DOI:10.1021/ja00457a032

Reference yield: 94.0%

(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester (53879-30-4,61990-36-1) → 2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester (80465-24-3)

Guidance literature:

With perchloric acid; In dichloromethane; water; at 15 - 20 ℃; for 1h; electrolysis;

DOI:10.1246/cl.1981.1575

Reference yield: 89.0%

(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid methyl ester (61990-36-1) → (R)-3-Chloromethyl-2-[(1R,5R)-3-(dichloro-phenyl-methyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl]-but-3-enoic acid methyl ester (91384-33-7)

Guidance literature:

With sulfuric acid; sodium chloride; In dichloromethane; water; Ambient temperature; electrolysis with Pt electrodes at a constant current (10 mA/cm²);

DOI:10.1002/bscb.19820911202

upstream raw materials:

methyl 6β-(phenylacetamido)penicillanate 1β-oxide

Downstream raw materials:

(R)-2-(2-benzyl-thiazole-4-carbonylamino)-3-methyl-but-3-enoic acid methyl ester

2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-2-enoic acid methyl ester

2-(7-oxo-2,6-diaza-4-thiabicyclo<3.2.0>hept-2-en-6-yl)-3-chloromethyl-3-butenoate

(E)-2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxy-but-2-enoic acid methyl ester