7-chloromethyloxycarbonylpaclitaxel

Base Information

Chemical Name:7-chloromethyloxycarbonylpaclitaxel
CAS No.:367527-76-2
Molecular Formula:C₄₉H₅₂ClNO₁₆
Molecular Weight:946.402
Hs Code.:

Synonyms:7-chloromethyloxycarbonylpaclitaxel

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Chemical Property of 7-chloromethyloxycarbonylpaclitaxel

Chemical Property:

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Technology Process of 7-chloromethyloxycarbonylpaclitaxel

There total 2 articles about 7-chloromethyloxycarbonylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 367527-75-1
(2'-(tert-butyldimethyl)silyloxy)-7-chloromethyloxycarbonylpaclitaxel

: 367527-76-2
7-chloromethyloxycarbonylpaclitaxel

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 114655-02-6
2'-O-(tert-butyldimethylsilyl)paclitaxel

: 367527-76-2
7-chloromethyloxycarbonylpaclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 15.17 h / 0 - 20 °C / Inert atmosphere

2: pyridine hydrogenfluoride / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.bioconjchem.6b00405

Reference yield: 60.0%

: 1151989-16-0
1-(pyridin-2-yldisulfanyl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid

: 367527-76-2
7-chloromethyloxycarbonylpaclitaxel

: 1151989-19-3
C₇₃H₉₂N₂O₂₆S₂

Guidance literature:: 7-chloromethyloxycarbonylpaclitaxel; With 18-crown-6 ether; potassium carbonate; In benzene; for 0.5h;

1-(pyridin-2-yldisulfanyl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; With sodium iodide; In benzene; for 2h; Heating / reflux;