3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

Base Information

Chemical Name:3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide
CAS No.:1352005-68-5
Molecular Formula:C₂₈H₂₃N₅O₂
Molecular Weight:461.523
Hs Code.:

Synonyms:3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

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Chemical Property of 3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

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Technology Process of 3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

There total 9 articles about 3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1352005-48-1
6-(3-bromophenyl)-2-ethyl-4-(isoquinolin-4-ylamino) pyridazin-3(2H)-one

: 351422-73-6
(3-(aminocarbonyl)phenyl)boronic acid

: 1352005-68-5
3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

Guidance literature:: With caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1532-97-4
4-bromoisoquinoline

: 1352005-68-5
3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

With potassium tert-butylate; caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; toluene;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352005-68-5
3'-[1-ethyl-5-(isoquinolin-4-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / ethanol; pentane; tetrahydrofuran; mineral oil / Cooling with ice

1.2: 20 - 40 °C / Reflux

1.3: pH 1 - 2

2.1: ethanol; sodium / 0.25 h / -5 - 0 °C

2.2: 0 - 20 °C

3.1: hydrazine hydrate / ethanol / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h

4.2: 20 - 30 °C

5.1: hydrogen / ethanol; tetrahydrofuran / 724.03 Torr

6.1: water; hydrogen bromide / 1.25 h / 130 °C

7.1: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

With ethanol; potassium tert-butylate; water; hydrogen bromide; hydrogen; sodium; sodium hydride; potassium carbonate; caesium carbonate; hydrazine hydrate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene; mineral oil; pentane;