4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

Base Information

Chemical Name:4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide
CAS No.:1414954-16-7
Molecular Formula:C₁₉H₂₀N₄O₃S
Molecular Weight:384.459
Hs Code.:

Synonyms:4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

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Chemical Property of 4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

Chemical Property:

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Technology Process of 4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

There total 5 articles about 4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1414956-61-8
7-iodo-4-(isopropylamino)cinnoline-3-carboxamide

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1414954-16-7
4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1414956-56-1
2-cyano-2-((3-iodophenyl)diazenyl)acetamide

: 1414954-16-7
4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / toluene / 150 °C / Sealed tube

2: potassium hydroxide / 1,4-dioxane / 110 °C

3: thionyl chloride

4: ammonium hydroxide

5: ethanol / 140 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane

With aluminum (III) chloride; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; potassium hydroxide; In 1,4-dioxane; ethanol; water; toluene; 6: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.11.021

Reference yield:

: 1414956-57-2
4-amino-7-iodocinnoline-3-carboxamide

: 1414954-16-7
4-(isopropylamino)-7-(4-(methylsulfonyl)phenyl)cinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / 1,4-dioxane / 110 °C

2: thionyl chloride

3: ammonium hydroxide

4: ethanol / 140 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; potassium hydroxide; In 1,4-dioxane; ethanol; water; 5: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.11.021